Commentary on CAM and NK Cells by Kazuyoshi Takeda and Ko Okumura

Activated NK Cells Apoptosis-Inducing Ligand on Murine Expression and Function of TNF-Related

CAM and NK Cells

It is believed that tumor development, outgrowth and metastasis are under the surveillance of the immune system. Although both innate and acquired immune systems play roles, innate immunity is the spearhead against tumors. Recent studies have revealed the critical role of natural killer (NK) cells in immune surveillance and that NK cell activity is considerably influenced by various agents, suc...

Natural killer cell lytic activity and CD56 and CD56 cell distributions during and after intensive training

Masatoshi Suzui, Takeshi Kawai, Hiroko Kimura, Kazuyoshi Takeda, Hideo Yagita, Ko Okumura, Pang N. Shek, and Roy J. Shephard School of Business Administration, Meiji University, Suginami, Tokyo 168-8555; School of Health and Sports Science, Juntendo University, Inba, Chiba 270-1695; School of Medicine, Juntendo University, Bunkyo, Tokyo, Japan 113-8421; Defence Research and Development Canada-T...

Interferon-γ-Mediated Natural Killer Cell Activation by an Aqueous Panax ginseng Extract

Panax ginseng extracts are used in traditional herbal medicines, particularly in eastern Asia, but their effect on natural killer (NK) cell activity is not completely understood. This study aimed to examine the effects of P. ginseng extracts on the cytotoxic activity of NK cells. We orally administered P. ginseng extracts or ginsenosides to wild-type (WT) C57BL/6 (B6) and BALB/c mice and to B6 ...

Runx proteins are involved in regulation of CD122, Ly49 family and IFN-gamma expression during NK cell differentiation.

Runx family proteins play indispensable roles in the development of various hematopoietic lineage cells. However, their function in NK cells is still uncertain. We found that NK cells and CD8 T cells dominantly express Runx3 protein, whereas NKT cells and CD4 T cells express Runx1. Reverse transcription-PCR analysis revealed that Runx3 expression is initiated at the NK precursor stage and is ma...